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Virustomycin A
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Virustomycin A图片
CAS NO:84777-85-5
包装与价格：
包装价格(元)
500μg电议
1mg电议
5mg电议

产品介绍
 
Cas No.84777-85-5
Canonical SMILESO=C1O[C@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](OC(/C=C/C(NC3=C(O)CCC3=O)=O)=O)[C@H](C)[C@@H](/C=C\C)O2)[C@@H](OC)/C=C/C=C(C)/C[C@@H](C)[C@H](O)[C@H](CC)[C@H](O)[C@H](C)/C=C(C)\C=C1\OC
分子式C48H71NO14
分子量886.1
溶解度Chloroform: soluble,Ethanol: soluble,Methanol: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Virustomycin A is a macrolide antibiotic originally isolated from Streptomyces.1,2 It is active against infectious and plant pathogenic fungi, including T. vaginalis and P. oryzae (MICs = 6.25 and 12.5 μg/ml, respectively), as well as the parasite T. foetus (MIC = 25 μg/ml).1 It also decreases plaque formation by RNA and DNA viruses (ED50 = 0.0003 μg/ml for all). Virustomycin A is active against the GUTat 3.1 strain of T. brucei brucei, but not the STIB900 strain of T. brucei rhodesiense (IC50s = 0.45 and 480 ng/ml, respectively), and induces cytotoxicity in human MRC-5 cells with an IC50 value of 80 ng/ml.3 It inhibits RNA, DNA, and protein synthesis in T. foetus.2

References
1. Omura, S., Shimizu, H., Iwai, Y., et al. AM-2604 A, a new antiviral antibiotic produced by a strain of Streptomyces. J. Antibiot. (Tokyo) 35(12), 1632-1637 (1982).
2. Omura, S., Otogguro, K., and Tanaka, H. The mode of action of a novel 18-membered macrolide, virustomycin A (AM-2604 A), on Trichomonas foetus. J. Antibiot. (Tokyo) 36(12), 1755-1761 (1983).
3. Otoguro, K., Ishiyama, A., Namatame, M., et al. Selective and potent in vitro antitrypanosomal activities of ten microbial metabolites. J.Antibiot.(Tokyo) 61(6), 372-378 (2008).