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CRANAD 28
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CRANAD 28图片
CAS NO:1623747-97-6
包装与价格:
包装价格(元)
500μg电议
1mg电议
5mg电议
10mg电议

产品介绍
CRANAD 28 是一种强大的荧光化合物,用于显示β淀粉样蛋白斑块。
Cas No.1623747-97-6
Canonical SMILES[F-][B+3]1([F-])[O]=C([CH-]C(/C=C/C2=C(C)N(C3=CC=CC=C3)N=C2)=[O]1)/C=C/C4=C(C)N(C5=CC=CC=C5)N=C4
分子式C27H23BF2N4O2
分子量484.3
溶解度DMF: 2 mg/ml,DMSO: 2 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CRANAD 28 is a curcumin derivative and non-conjugated fluorescent affinity probe for the detection of amyloid-β (Aβ) in vitro and in vivo that has excitation/emission spectra of 498/578 nm, respectively. It binds to various forms of Aβ, including Aβ40 monomers and aggregates, as well as Aβ42 monomers, dimers, and oligomers (Kds = 68.8, 52.4, 159.7, 162.9, and 85.7 nM, respectively). When bound to Aβ, the fluorescence intensity decreases, in contrast to similar curcumin-based fluorescent probes. CRANAD 28 labels amyloid plaques and cerebral amyloid angiopathy both in APP/PS1 mouse brain sections and in live mice following i.v. administration. It also inhibits copper-induced and naturally occurring Aβ crosslinking.