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PF 4778574
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF 4778574图片
CAS NO:1219633-99-4
包装:10mg
市场价:1880元

产品介绍
PF 4778574 是 AMPA 受体的正向变构调节剂,在不同细胞中的 EC50 为 45 至 919 nM。
Cas No.1219633-99-4
化学名N-((3R,4S)-3-(4-(5-cyanothiophen-2-yl)phenyl)tetrahydro-2H-pyran-4-yl)propane-2-sulfonamide
Canonical SMILESCC(S(N[C@@]1([H])CCOC[C@]1([H])C2=CC=C(C3=CC=C(S3)C#N)C=C2)(=O)=O)C
分子式C19H22N2O3S2
分子量390.52
溶解度<39.05mg/ml in DMSO;<19.53mg/ml in ethanol
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PF-4778574 is a positive allosteric modulation of AMPA receptor with EC50 of 45 to 919 nM in differenct cells.

References:
[1]. Roberts BM, et al. Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction. Behav Brain Res. 2010 Sep 1;212(1):41-8.