包装: | 100μg |
市场价: | 4841元 |
Canonical SMILES | CCC(C(/N=C(O)/C/N=C(O)/C(N)C(C)C)/C(O)=N/C(/C(O)=N/C(/C(O)=N/C(/C(O)=N/C(/C(O)=N\C(/C(O)=N/C(/C(O)=N/C(/C(O)=N/C(/C(O)=N\C(/C(O)=N/C(C(O)=NC(C(O)=NC(C1=O)CCCCN)CC(C)C)CSSCC2/C(O)=N/C(/C(O)=N/C(/C(O)=N/C(C(N3CCCC3/C(O)=N/C(C(O)=O)CCCCN)=O)C(O)C)CSSCC(N=C(O |
分子式 | C169H281N57O46S7 |
分子量 | 4071.85 |
溶解度 | Soluble to 2 mg/ml in Water |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | ADWX 1 is a potent and selective inhibitor of KV1.3 channel with IC50 values of 1.89 pM and 0.65 nM for Kv1.3 and Kv1.1, respectively [1]. Potassium voltage-gated channel (KV1.3 channel) is a potassium channel and plays an important role in regulating Ca2+ signaling and the resting membrane potential. KV1.3 is an attractive target for immunomodulation of T cell-mediated autoimmune diseases [1]. ADWX 1 is a potent and selective KV1.3 channel inhibitor. In the transiently transfected HEK293 cells, ADWX-1 inhibited potassium channel with IC50 values of 1.89 pM and 0.65 nM for Kv1.3 and Kv1.1, respectively [1]. In a rat experimental autoimmune encephalomyelitis (EAE) model, ADWX-1 lowered the clinical scores and significantly reduced inflammatory infiltrates. Also, ADWX-1 reduced the levels of IL-2 and IFN-γ. In MBP-stimulated PBMCs from ADWX-1-treated EAE rats, IL-2 secretion was decreased significantly. In the EAE model, the CD4+CCR7- TEM cells were inhibited by ADWX-1. Also, ADWX-1 inhibited IL-2 secretion by CD4+CCR7- TEM cells through the NF-B- and NF-AT-dependent way [2]. References: |