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TCN 237 dihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TCN 237 dihydrochloride图片
CAS NO:700878-19-9
包装:10mg
市场价:1229元

产品介绍
TCN 237 dihydrochloride 是一种有效的 NR2B 选择性 NMDA 拮抗剂,Ki 为 0.85 nM; NR2B Ca2+ 内流 IC50 为 9.7 nM;对 NR2A、NR2C、NR2D、hERG 通道和 α1-肾上腺素能受体无活性。
Cas No.700878-19-9
化学名2-((4-(2-fluorobenzyl)piperidin-1-yl)methyl)-1H-benzo[d]imidazol-6-ol dihydrochloride
Canonical SMILESFC1=CC=CC=C1CC2CCN(CC3=NC4=C(N3)C=C(O)C=C4)CC2.Cl.Cl
分子式C20H22FN3O.2HCl
分子量412.33
溶解度Soluble to 100 mM in sterile water
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

NMDA-IN-1 is a potent and NR2B-selective NMDA antagonist with Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM; no activities on NR2A, NR2C, NR2D, hERG-channel and α1-adrenergic receptor.

References:
[1]. McCauley JA, et al. NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles. J Med Chem. 2004 Apr 8;47(8):2089-96.