CAS NO: | 52549-17-4 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
100mg | 电议 |
500mg | 电议 |
1 g | 电议 |
5 g | 电议 |
生物活性 | Pranoprofen is a non-steroidal anti-inflammatory agent (NSAID) for the research of keratitis or other ophthalmology diseases. Pranoprofen inhibitCOX-1andCOX-2enzymes, thus blocking arachidonic acid converted to eicosanoids and reducing prostaglandins synthesis[1][2]. | ||||||||||||||||
IC50& Target[2] |
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体外研究 (In Vitro) | Pranoprofen (pretreatment for 1 h; 1 mM) has an inhibitory effect against ER stress-induced GRP78 and CHOP expression in glial cells[1].Pranoprofen (5-25 μM; 24 h) dose-dependently enhances Dicer expression. Additionally, Pranoprofen at 5 μM enhances H2O2 (800 μM)-induced Dicer expression in FHC cells[3]. | ||||||||||||||||
体内研究 (In Vivo) | Pranoprofen (oral administration; 4 mg/kg/16 mg/kg; 9 days) rescues Dicer expression in inflamed colon tissues, alleviates colitis and prevents colitis-associated colon cancers in C57BL/6 mice[3].Dicer is a key component of the RNA interference pathway and is essential for the biogenesis of miRNAs and siRNAs.
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Clinical Trial | |||||||||||||||||
分子量 | 255.27 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C15H13NO3 | ||||||||||||||||
CAS 号 | 52549-17-4 | ||||||||||||||||
中文名称 | 普拉洛芬 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 100 mg/mL(391.74 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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