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Avatrombopag-d8 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Avatrombopag-d8 hydrochloride图片
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品名称
AKR-501-d8 hydrochloride
E5501-d8 hydrochloride
YM477-d8 hydrochloride
产品介绍
Avatrombopag-d8 (hydrochloride) 是 Avatrombopag (hydrochloride) 氘代物。Avatrombopag (AKR-501) hydrochloride 是一种口服活性的非肽血小板生成素受体(TPO receptor)激动剂 (EC50=3.3 nM)。Avatrombopag hydrochloride 可模拟TPO 的生物活性。Avatrombopag hydrochloride 通过激活细胞内信号传导系统来增加血小板的产生,并促进造血前体细胞产生血小板和巨核细胞。Avatrombopag hydrochloride 是细胞色素 P450 (CYP) 2C9 和 CYP3A 的底物。
生物活性

Avatrombopag-d8 (hydrochloride) is deuterium labeled Avatrombopag (hydrochloride). Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC50=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate ofcytochrome P450(CYP) 2C9 and CYP3A[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

分子量

694.16

Formula

C29H27D8Cl3N6O3S2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.