Pam3CSK4 TFA 是一种 Toll 样受体 1/2 (TLR1/2) 激动剂，对人 TLR1/2 的EC50为 0.47 ng/mL。
| 生物活性 | Pam3CSK4 TFA is atoll-like receptor1/2 (TLR1/2) agonist with anEC50of 0.47 ng/mL for human TLR1/2[1]. |
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体外研究
(In Vitro) | Pam3CSK4 is a TLR1/2 heterodimer recognises triacylated lipopeptides[1].
Pam3CSK4 (1 μg/mL) enhances the antibacterial functions of granulocyte macrophage-colony stimulating factor (GM-CSF) induced neutrophils to Methicillin-resistantStaphylococcus aureus(MRSA)[2].
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体内研究
(In Vivo) | Pam3CSK4 (5 mg/kg; i.p.; once a day for 9 days) alters brain, spleen and liver weights in neonatal mice[3].
| Animal Model: | Time-mated pregnant C57BL/6 wild-type mice; B6.129-Tlr2tm1Kir/J (TLR2 -deficient) mice[3] | | Dosage: | 5 mg/kg | | Administration: | Intraperitoneally (i.p.); once a day for 9 days | | Result: | After repeated administration from postnatal day (PND3) to PND11, brain weight was decreased compared with endotoxin-free saline-treated animals at PND12. Decreased volume of cerebral gray matter, white matter in the forebrain and cerebellar molecular layer that was accompanied by an increase in spleen and liver weight at PND12. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Sealed storage, away from moisture | Powder | -80°C | 2 years | | -20°C | 1 year |
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| 溶解性数据 | In Vitro: DMSO : 50 mg/mL(26.99 mM;Need ultrasonic) H2O : 16.67 mg/mL(9.00 mM;Need ultrasonic) 配制储备液 | 1 mM | 0.5399 mL | 2.6993 mL | 5.3986 mL | | 5 mM | 0.1080 mL | 0.5399 mL | 1.0797 mL | | 10 mM | 0.0540 mL | 0.2699 mL | 0.5399 mL |
*请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。 |
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