CAS NO: | 478148-58-2 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | PHA-543613 dihydrochloride is a potent, orally active, brain-penetrant and selectiveα7nAChRagonist with aKivalue of 8.8 nM. PHA-543613 dihydrochloride displays selectivity for α7-nAChR over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors[1]. PHA-543613 dihydrochloride can be used for the cognitive deficits of Alzheimer's disease and schizophrenia research[2][3]. | ||||||||
IC50& Target | Ki: 8.8 nM (α7 nAChR)[1] | ||||||||
体内研究 (In Vivo) | PHA-543613 dihydrochloride (0.3 mg/kg) successfully reverses Scopolamine-induced short-term memory deficits in rats[2].PHA-543613 dihydrochloride (4 and 12 mg/kg; i.p. once) reduces behavioral deficits and brain edema is dependent on the PI3K-Akt signaling pathway[3].
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分子量 | 344.24 | ||||||||
Formula | C15H19Cl2N3O2 | ||||||||
CAS 号 | 478148-58-2 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |