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Bumetanide sodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bumetanide sodium图片
CAS NO:28434-74-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
Ro 10-6338 sodium
PF 1593 sodium
产品介绍
Bumetanide sodium 是一种高效的利尿剂,是 Na+-K+-Cl+协同转运蛋白 (NKCC) 的阻断剂。Bumetanide sodium 是选择性的NKCC1抑制剂,但对 NKCC2 也有抑制作用,对 hNKCC1A 和 hNKCC2A 作用的IC50值分别为 0.68 和 4.0 μM。
生物活性

Bumetanide sodium, a highly potent loop diuretic, is aNa+-K+-Cl+cotransporter (NKCC)blocker. Bumetanide sodium is a selectiveNKCC1inhibitor, and also inhibits NKCC2, withIC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively[1][2].

体外研究
(In Vitro)

Bumetanide sodium has inhibitory effects for the two major human splice variants of NKCCs, hNKCC1A and hNKCC2A[1].
Bumetanide sodium (0.03-100 μM; 5 minutes) inhibits the86Rb+uptake in NKCC1A-expressing oocytes in a dose-dependent manner[1].
Bumetanide sodium inhibits NKCC2 isoform B in HEK-293 cells with an IC50value of 0.54 μM[2].

体内研究
(In Vivo)

Bumetanide sodium (7.6-30.4 mg/kg; i.v.) attenuates the decrease in apparent diffusion coefficients (ADC) ratios for both cortex and striatum (by 40-67%), indicating reduced edema formation[3].
Bumetanide sodium also reduces infarct size[3].
Bumetanide sodium shows different half-lives of 21.4 min, 53.8 min and 137 min following 2 mg/kg, 8 mg/kg and 20 mg/kg intravenous injection, respectively, in rats[4].

Clinical Trial
分子量

386.40

Formula

C17H19N2NaO5S

CAS 号

28434-74-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.