CAS NO: | 28434-74-4 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Bumetanide sodium, a highly potent loop diuretic, is aNa+-K+-Cl+cotransporter (NKCC)blocker. Bumetanide sodium is a selectiveNKCC1inhibitor, and also inhibits NKCC2, withIC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively[1][2]. |
体外研究 (In Vitro) | Bumetanide sodium has inhibitory effects for the two major human splice variants of NKCCs, hNKCC1A and hNKCC2A[1]. |
体内研究 (In Vivo) | Bumetanide sodium (7.6-30.4 mg/kg; i.v.) attenuates the decrease in apparent diffusion coefficients (ADC) ratios for both cortex and striatum (by 40-67%), indicating reduced edema formation[3]. |
Clinical Trial | |
分子量 | 386.40 |
Formula | C17H19N2NaO5S |
CAS 号 | 28434-74-4 |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |