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Adenosine 5′-diphosphoribose sodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Adenosine 5′-diphosphoribose sodium图片
CAS NO:68414-18-6
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议

产品名称
二磷酸腺苷核糖
ADP ribose sodium
产品介绍
Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) 是一种烟酰胺腺嘌呤核苷酸 (NAD+) 的代谢产物,也是一种最有效和最主要的细胞内 Ca2+渗透性阳离子TRPM2通道激活剂,还可以增强自噬 (autophagy)。
生物活性

Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca2+-permeable cationTRPM2 channelactivator. Adenosine 5′-diphosphoribose sodium also can enhanceautophagy[1][2].

IC50& Target

TRPM2 channel[1][2]
Autophagy[1]

体外研究
(In Vitro)

In mouse embryonic fibroblasts (MEFs), H2O2treatment demonstrates that the activation of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) produced Adenosine 5′-diphosphoribose (ADP ribose), which is an activating signal for TRPM2 channels, thereby promoting Ca2+elevation through extracellular Ca2+influx and (or) lysosomal Ca2+release. This process eventually activates early or late autophagy in response to different degrees of oxidative stress[1][1].
TRPM2 channels are activated by binding of Adenosine 5′-diphosphoribose (ADP ribose) to the intracellular NUDT9-homology (NUDT9-H) domain unique to TRPM2 and located at its C terminus. In addition to ADPR, intracellular Ca2+is an essential coactivator: TRPM2 channels open only in the combined presence of both ligands[2].

Clinical Trial
分子量

581.30

性状

Solid

Formula

C15H22N5NaO14P2

CAS 号

68414-18-6

中文名称

二磷酸腺苷核糖

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : 125 mg/mL(215.04 mM;Need ultrasonic)

DMSO : 25 mg/mL(43.01 mM;ultrasonic and warming and heat to 80℃)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.7203 mL8.6014 mL17.2028 mL
5 mM0.3441 mL1.7203 mL3.4406 mL
10 mM0.1720 mL0.8601 mL1.7203 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: PBS

    Solubility: 100 mg/mL (172.03 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。