CAS NO: | 68414-18-6 |
包装 | 价格(元) |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca2+-permeable cationTRPM2 channelactivator. Adenosine 5′-diphosphoribose sodium also can enhanceautophagy[1][2]. | ||||||||||||||||
IC50& Target | TRPM2 channel[1][2] | ||||||||||||||||
体外研究 (In Vitro) | In mouse embryonic fibroblasts (MEFs), H2O2treatment demonstrates that the activation of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) produced Adenosine 5′-diphosphoribose (ADP ribose), which is an activating signal for TRPM2 channels, thereby promoting Ca2+elevation through extracellular Ca2+influx and (or) lysosomal Ca2+release. This process eventually activates early or late autophagy in response to different degrees of oxidative stress[1][1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 581.30 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C15H22N5NaO14P2 | ||||||||||||||||
CAS 号 | 68414-18-6 | ||||||||||||||||
中文名称 | 二磷酸腺苷核糖 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : 125 mg/mL(215.04 mM;Need ultrasonic) DMSO : 25 mg/mL(43.01 mM;ultrasonic and warming and heat to 80℃) 配制储备液
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