CAS NO: | 2595314-46-6 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | WEHI-9625 is a tricyclic sulfone, first-in-class inhibitor ofapoptosiswith anEC50of 69 nM. WEHI-9625 binds toVDAC2and promotes its ability to inhibitapoptosisdriven by mouseBAK. WEHI-9625 is completely inactive against both humanBAKand the closely relatedapoptosiseffectorBAX[1]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | WEHI-9625 (0-10 μM; Mcl1–/–Bax–/–MEFs cells) treatment could prevent cell death mediated by BAK and potently inhibits BIM BH3-induced loss of mitochondrial membrane potential in Bax–/–, but not Bak–/–, cells[1]. Cell Viability Assay[1]
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体内研究 (In Vivo) | WEHI-9625 demonstrates that blocking apoptosis at an early stage was both advantageous and pharmacologically tractable[1]. | ||||||||||||||||
分子量 | 593.71 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C34H27NO5S2 | ||||||||||||||||
CAS 号 | 2595314-46-6 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(168.43 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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