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Lonodelestat TFA
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Lonodelestat TFA图片
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
POL6014 TFA
产品介绍
Lonodelestat TFA (POL6014 TFA) 是有效的、具有口服活性的、选择性的人中性粒细胞弹性蛋白酶(hNE)的肽类抑制剂。Lonodelestat TFA 具有囊性纤维化 (CF) 研究的潜力 .
生物活性

Lonodelestat TFA (POL6014 TFA) is a potent, orally active and selective peptide inhibitor ofhuman neutrophilelastase(hNE). Lonodelestat TFA has the potential for the research of cystic fibrosis (CF)[1][2][3].

体内研究
(In Vivo)

Lonodelestat (POL6014) significantly and efficiently reduced the inflammatory processes of ALI in HNE treated mice[1].
Lonodelestat (POL6014, 0.1, 0.5, 2 and 10 mg/kg, intranasally administered) dose-dependently and significantly reduces the number of macrophages, epithelial cells, neutrophils and lymphocytes recovered in BAL. The maximum inhibition was reached at 2 mg/kg in reducing neutrophils by 65% (p<0.001), epithelial cells by 68% (p<0.001), macrophages by 33% (p<0.001) and lymphocytes by 77% (p<0.001)[1].

分子量

1592.75

Formula

C73H112F3N15O21

Sequence

cyclo[ASIPPQKYPPNle(bu)ET]

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.