您好，欢迎来到化工原料网！ [登录] [免费注册]
化工原料网
发布求购
位置：首页 > 产品库 > MitoTEMPO(hydrate)
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
MitoTEMPO(hydrate)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
MitoTEMPO(hydrate)图片
CAS NO:1569257-94-8
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Cas No.1569257-94-8
化学名2,2,6,6-tetramethyl-4-[[2-(triphenylphosphonio)acetyl]amino]-1-piperidinyloxy, monochloride, monohydrate
Canonical SMILESO=C(NC1CC(C)(C)N([O])C(C)(C)C1)C[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.[Cl-].O
分子式C29H35N2O2P•Cl [H2O]
分子量528
溶解度DMF: 15 mg/ml,DMSO: 10 mg/ml,Ethanol: 15 mg/ml,PBS (pH 7.2): 5 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

MitoTEMPO is a mitochondria-targeted superoxide dismutase mimetic that possesses superoxide and alkyl radical scavenging properties.[1] This compound combines the antioxidant piperidine nitroxide TEMPO with the lipophilic cation triphenylphosphonium, which allows it to pass through lipid bilayers and accumulate in mitochondria. Mitochondrial targeting of superoxide scavenging via mitoTEMPO has been examined for potential therapeutic benefit to a variety of mitochondrial dysfunctions arising from excessive reactive oxygen species.[2][3][4]

Reference:
[1]. Dikalov, S. Cross talk between mitochondria and NADPH oxidases. Free Radical Biology & Medicine 51(7), 1289-1301 (2011).
[2]. Liang, H.L., Arsenault, J., Mortensen, J., et al. Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cells. Apoptosis 14(10), 1176-1189 (2009).
[3]. Dikalova, A.E., Bikineyeva, A.T., Budzyn, K., et al. Therapeutic targeting of mitochondrial superoxide in hypertension. Circulation Research 107(1), 106-116 (2010).
[4]. Liang, H.L., Sedlic, F., Bosnjak, Z., et al. SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery. Free Radical Biology & Medicine 49(10), 1550-1560 (2010).
Product Citations