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Indoxyl Sulfate(potassium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Indoxyl Sulfate(potassium salt)图片
CAS NO:2642-37-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
Indoxyl Sulfate(钾盐)是一种内源性代谢物。
Cas No.2642-37-7
别名硫酸吲哚钾盐
化学名3-(hydrogen sulfate), 1H-indol-3-ol, monopotassium salt
Canonical SMILES[O-]S(OC1=CNC2=CC=CC=C21)(=O)=O.[K+]
分子式C8H6NO4S o K
分子量251.3
溶解度30mg/mL in DMSO or DMF
储存条件Store at -20°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Indoxyl sulfate is a metabolite of tryptophan derived from dietary protein. Tryptophan is metabolized by intestinal bacteria into indole, which is absorbed into the blood and then further metabolized to indoxyl sulfate in the liver, which is normally excreted in urine. In chronic kidney disease patients where renal function is compromised, indoxyl sulfate can accumulate in serum as a uremic toxin, inducing oxidative stress and accelerating progression of the disease. [1] Indoxyl sulfate at 250 &#181M can induce the activation of NF-κB, promoting the expression of both TGF-β1 and Smad3 expression in proximal tubular cells of rats, which is associated with profibrotic activity.[2]

Reference:
[1]. Niwa, T. Uremic toxicity of indoxyl sulfate. Nagoya J.Med.Sci. 72(1-2), 1-11 (2010).
[2]. Shimizu, H., Yisireyili, M., Nishijima, F., et al. Indoxyl sulfate enhances p53-TGF-β1-Smad3 pathway in proximal tubular cells. Am.J.Nephrol. 37(2), 97-103 (2013).