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Garadacimab
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:2162134-62-3
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品名称
CSL312
产品介绍
Garadacimab (CSL312) 是一流的全人 IgG4 单克隆抗体,靶向活化因子 XII (FXIIa)。Garadacimab 具有用于遗传性血管性水肿研究的潜力。
生物活性

Garadacimab (CSL312) is a first-in-class, fully humanIgG4monoclonal antibody targetingactivated factor XII (FXIIa). Garadacimab has the potential for hereditary angioedema research[1].

体外研究
(In Vitro)

Garadacimab (CSL312) displays high affinity to activated βFXIIa with a KDof 140 pM and shows potency in an activated partial thromboplastin time (aPTT) assay with human plasma. Garadacimab shows high selectivity over a panel of relevant human serine proteases (FVIIa, FIXa, FXa, FXIa, kallikrein, tissue plasminogen activator, activated protein C, and urokinase plasminogen activator)[2].

体内研究
(In Vivo)

In male and female cynomolgus monkeys, Garadacimab (0.5, 1, and 3 mg/kg i.v. and 6 and 20 mg/kg s.c. over 8 weeks) plasma concentrations increased in a dose-dependent manner[1].
Garadacimab has an inhibitory effect on FXII-mediated kallikrein activity. Furthermore, Garadacimab causes a clear dose-dependent prolongation of activated partial thromboplastin time (aPTT) with no associated effect on the prothrombin time[1].

CAS 号

2162134-62-3

中文名称

加达西单抗

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.