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Hexamethonium Bromide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hexamethonium Bromide图片
CAS NO:55-97-0
包装:50mg
市场价:494元

产品介绍
Hexamethonium Bromide 是一种非选择性神经节烟碱受体拮抗剂 (nAChR) 拮抗剂,具有混合的竞争性和非竞争性活性。
Cas No.55-97-0
别名六甲溴铵
化学名trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;dibromide
Canonical SMILESC[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-]
分子式C12H30N2.2Br
分子量362.19
溶解度≥ 36.6mg/mL in Water, ≥ 36.3mg/mL in DMSO with gentle warming, ≥ 36.2mg/mL in EtOH with gentle warming
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Hexamethonium Bromide is a non-depolarising ganglionic blocker, a nicotinic nACh (NN) receptor antagonist.Target: nAChRHexamethonium Bromide is a non-depolarising ganglionic blocker, a nicotinic nACh receptor antagonist that acts in autonomic ganglia by binding mostly in or on the NN receptor, and not the acetylcholine binding site itself. It does not have any effect on the muscarinic acetylcholine receptors (mAChR) located on target organs of the parasympathetic nervous system but acts as antagonist at the nicotinic acetylcholine receptors located in sympathetic and parasympathetic ganglia (NN). Hexamethonium Bromide is a nicotinic acetyl choline receptor antagonist. Induces apoptosis and inhibits the stimulatory effect of nicotine on endothelial cell DNA synthesis and proliferation. Hexamethonium bromide hydrate is an inhibitor of AChR α3 [1-3].

References:
[1]. Maneckjee, R. and J.D. Minna, Opioids induce while nicotine suppresses apoptosis in human lung cancer cells. Cell Growth Differ, 1994. 5(10): p. 1033-40.
[2]. Sanchez-Fortun, S., F. Sanz, and M.V. Barahona, Acute toxicity of several organophosphorous insecticides and protection by cholinergic antagonists and 2-PAM on Artemia salina larvae. Arch Environ Contam Toxicol, 1996. 31(3): p. 391-8.
[3]. Villablanca, A.C., Nicotine stimulates DNA synthesis and proliferation in vascular endothelial cells in vitro. J Appl Physiol (1985), 1998. 84(6): p. 2089-98.