CAS NO: | 365462-23-3 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Darexaban (YM150) is a potent, selective and orally activefactor Xa(FXa)inhibitor with anIC50of 54.6 nM. Darexaban shows high selectivity against other related serine proteases, such as trypsin,thrombin, and kallikrein. Darexaban has anticoagulant and antithrombotic effects[1][2][3]. | ||||||||||||||||
体外研究 (In Vitro) | Darexaban is an oral direct factor Xa (FXa) inhibitor that is rapidly and extensively metabolized into its glucuronide conjugate (YM-222714) post-administration. Darexaban competitively and selectively inhibits human FXa, and also inhibits the prothrombin activation induced by prothrombinase complex or whole blood clot with similar potency to free FXa[2]. | ||||||||||||||||
体内研究 (In Vivo) | In mice, Darexaban inhibits FXa activity in plasma with an ED50value of 24.8 mg/kg. Darexaban prolonges prothrombin time (PT) at 3 mg/kg[2]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 474.55 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C27H30N4O4 | ||||||||||||||||
CAS 号 | 365462-23-3 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 250 mg/mL(526.81 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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