Meclofenamic acid (Meclofenamate) sodium hydrate is a non-steroidal anti-inflammatory agent. Meclofenamic acid sodium hydrate is a highly selectiveFTO(fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid sodium hydrate competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid sodium hydrate is a non-selectivegap-junctionblocker. Meclofenamic acid sodium hydrate inhibitshKv2.1andhKv1.1, withIC₅₀values of 56.0 and 155.9 μM, respectively^[1][2][3][4].

Meclofenamic acid sodium hydrate (0-100 μM, 24 h) inhibits FTO demethylation in a dose-response manner^[1].
Meclofenamic acid sodium hydrate inhibits enzyme cyclooxygenase, with an IC₅₀about 1 μM, thereby inhibiting the production of prostaglandins^[2].
Meclofenamic acid sodium hydrate inhibits the release of 5-HETE and LTB4 from human neutrophils stimulated with calcium ionophore and antagonizes the response of tissues to certain prostaglandins^[2].

336.15

C₁₄H₁₂Cl₂NNaO₃

67254-91-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.