CAS NO: | 20362-54-3 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | FBPase-IN-1 is a potentFBPase(Fructose-1,6-bisphosphatase) inhibitor for Type 2 diabetes (T2D) study with anIC50of 0.22 μM. FBPase-IN-1 can reduce blood glucose levels and ameliorate glucose tolerance. FBPase-IN-1 modifies the C128 site, regulates the N125-S124-S123 allosteric pathway ofFBPaseand affects the catalytic activity ofFBPase[1]. | ||||||||||||||||
IC50& Target | IC50: 0.22 μM (FBPase)[1] | ||||||||||||||||
体外研究 (In Vitro) | FBPase-IN-1 (compund 3a) (1.5625-200 μM, 48 hours) shows a low cytotoxicity with anIC50of 75.08 μM[1]. | ||||||||||||||||
体内研究 (In Vivo) | FBPase-IN-1 (12 h-fasted ICR mouse, n = 6, male, 25 mg/kg, IP) shows good FBPase inhibitory activity (IC50= 0.22 μM), satisfying glucose-lowering effectin vivo(54% reduction in blood glucose at 25 mg/kg)[1].
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分子量 | 232.37 | ||||||||||||||||
Formula | C6H4N2S4 | ||||||||||||||||
CAS 号 | 20362-54-3 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |