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FBPase-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FBPase-IN-1图片
CAS NO:20362-54-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
FBPase-IN-1 是一种有效的FBPase(Fructose-1,6-bisphosphatase) 抑制剂,IC50为 0.22 μM,可用于二型糖尿病研究。FBPase-IN-1 可降低血糖水平,改善糖耐量。FBPase-IN-1 修饰 C128 位点,调控 FBPase 的 N125-S124-S123 变构通路,影响FBPase的催化活性。
生物活性

FBPase-IN-1 is a potentFBPase(Fructose-1,6-bisphosphatase) inhibitor for Type 2 diabetes (T2D) study with anIC50of 0.22 μM. FBPase-IN-1 can reduce blood glucose levels and ameliorate glucose tolerance. FBPase-IN-1 modifies the C128 site, regulates the N125-S124-S123 allosteric pathway ofFBPaseand affects the catalytic activity ofFBPase[1].

IC50& Target

IC50: 0.22 μM (FBPase)[1]

体外研究
(In Vitro)

FBPase-IN-1 (compund 3a) (1.5625-200 μM, 48 hours) shows a low cytotoxicity with anIC50of 75.08 μM[1].
FBPase-IN-1 (0-45 min) inhibits FBPase in a time-dependent manner, withIC50decreasing from 0.28 to 0.09 μM, shows FBPase-IN-1 is an irreversible covalent inhibitor of FBPase[1].

体内研究
(In Vivo)

FBPase-IN-1 (12 h-fasted ICR mouse, n = 6, male, 25 mg/kg, IP) shows good FBPase inhibitory activity (IC50= 0.22 μM), satisfying glucose-lowering effectin vivo(54% reduction in blood glucose at 25 mg/kg)[1].
FBPase-IN-1 (6 or 7 weeks, ICR mice, n = 6, male, 25 mg/kg, IP for 4 hours, once) reduces blood glucose levels by targeting FBPase and inhibiting the GNG process[1].

Animal Model:ICR mouse (12 h-fasted, n = 6, male)[1]
Dosage:25 mg/kg
Administration:IP, once
Result:Lowered glucose.
Animal Model:ICR mice (6 or 7 weeks, n = 6, male)[1]
Dosage:25 mg/kg
Administration:IP, for 4 h, once
Result:Reduced blood glucose levels by targeting FBPase and inhibiting the GNG process.
分子量

232.37

Formula

C6H4N2S4

CAS 号

20362-54-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.