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MK-0941 free base
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MK-0941 free base图片
CAS NO:752240-01-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
MK-0941 free base 是具有口服活性的葡糖激酶 (glucokinase) 抑制剂,在葡萄糖浓度为 2.5 和 10 mM 的条件下,对重组人 glucokinase 的EC50值分别为 240 和 65 nM。MK-0941 free base 具有较强的降血糖活性,是研究 2 型糖尿病的候选药物。
生物活性

MK-0941 free base is an orally activeglucokinaseactivator, withEC50s of 240 and 65 nM for recombinant humanglucokinasein the presence of 2.5 and 10 mM glucose, respectively. MK-0941 free base exhibits strong glucose-lowering activity and is a potential therapeutic agent for treatment of type 2 diabetes[1][2].

IC50& Target

Glucokinase[1][2].

体内研究
(In Vivo)

MK-0941 free base (3 or 10 mg/kg, sing oral dose) treatment reduced blood glucose significantly indb/dbdiabetic mouse[1].

Animal Model:Maledb/dbanddb/+ (lean) mice (9-10 weeks of age, weighing 43-45 g)[1].
Dosage:3 or 10 mg/kg.
Administration:Oral gavage, single dose.
Result:Resulted in significant reduction in blood glucose. These two doses lowered blood glucose similarly at 1 h after dosing, suggesting that saturation of effect was approached.
Clinical Trial
分子量

460.50

Formula

C21H24N4O6S

CAS 号

752240-01-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.