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Fucoidan
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:9072-19-9
包装与价格:
包装价格(元)
500mg电议
1 g电议
5 g电议

产品名称
岩藻多糖;褐藻糖胶
产品介绍
Fucoidan 是一种生物活性多糖,是 α-淀粉酶和 α-葡萄糖苷酶的有效抑制剂。 具有抗凝血,抗肿瘤,抗氧化和抗脂肪活性。
生物活性

Fucoidan, a biologically active polysaccharide, is an efficient inhibitor of α-amylase and α-glucosidase. Anticoagulant, antitumor, antioxidant and antisteatotic activities[1].

体外研究
(In Vitro)

Fucoidan is a biologically active polysaccharide found in great abundance in brown marine algae[1].
Fucoidan extracted fromA. nodosumis a more potent inhibitor of α-glucosidase, with an IC50ranging from 0.013 to 0.047 mg/mL, than the inhibition by Fucoidan extracted fromF. vesiculosus(IC50=0.049 mg/mL). Fucoidan extracted fromF. vesiculosusdoes not inhibit α-amylase activity, while Fucoidan fromA. nodosumdecreases α-amylase activity by 7-100% at 5 mg/mL depending upon the algae harvest period. Fucoidan fromA. nodosuminhibits α-amylase with an IC50of 0.12-4.64 mg/mL[1].
Fucoidan is a fucose-rich sulfated polysaccharide typically found in the cell wall of marine algae but also recently isolated from terrestrial sources. Fucoidan exhibits an attractive therapeutic potential against a wide array of metabolic diseases associated with oxidative stress[2].

体内研究
(In Vivo)

Fucoidan (single injection of 25 mg/kg/body) does not inhibit tumor cell proliferation, while three-time injections of 10 mg/kg/body weight significantly reduces tumor growth and metastasis[3].

Animal Model:Mice[3]
Dosage:10-400 mg/kg
Administration:Intraperitoneal injection; followed by total-body irradiation
Result:The mice injected with 100 mg/kg showed the best survival rate at 30 days post-irradiation.
Clinical Trial
性状

Solid

CAS 号

9072-19-9

中文名称

岩藻多糖;褐藻糖胶

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

H2O : 20 mg/mL(ultrasonic and warming and heat to 60℃)

DMSO :< 1 mg/mL (ultrasonic;warming;heat to 60℃)(insoluble or slightly soluble)

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: PBS

    Solubility: 33.33 mg/mL (Infinity mM); Clear solution; Need ultrasonic and warming and heat to 60℃

*以上所有助溶剂都可在本网站选购。