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Cystamine(dihydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cystamine(dihydrochloride)图片
CAS NO:56-17-7
包装与价格:
包装价格(元)
10 g电议
50 g电议

产品介绍
Cystamine (dihydrochloride) 是游离硫醇半胱胺的二硫化物形式。Cystamine 是一种转谷氨酰胺酶 (Tgase) 抑制剂,具有口服活性。Cystamine 对 caspase-3 也有抑制活性,IC50值为 23.6 μM。Cystamine 可用于亨廷顿舞蹈病(HD)等多种疾病的研究。
生物活性

Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally activetransglutaminase (Tgase)inhibitor. Cystamine also has inhibition activity for caspase-3 with anIC50value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD)[1][2][3].

IC50& Target[1]

Caspase 3

23.6 μM (IC50)

体外研究
(In Vitro)

Cystamine (dihydrochloride) has inhibition activity for caspase-3 with an IC50value of 23.6 μM[1].
Cystamine (0-500 μM; 0-16 h) inhibits recombinant active caspase-3 in a concentration-dependent manner[1].
Cystamine (250 μM; 10 h) robustly increases the levels of glutathione[1].

Western Blot Analysis[1]

Cell Line:Human neuroblastoma SH-SY5Y cells
Concentration:250, 500 μM
Incubation Time:0-16 h
Result:Inhibited the MG132-mediated activation of caspase-3.
Inhibited the H2O2-mediated activation of caspase-3.
Inhibited caspase-3 activity in a tTG-independent manner.
体内研究
(In Vivo)

Cystamine (dihydrochloride) (oral, i.p.; 112, 225 mg/kg) reduces Tgase activity and GGEL levels, lessens the behavioral and neuropathological severity, and extends survival in R6/2 transgenic HD mice[2].

Animal Model:R6/2 transgenic HD mice[2]
Dosage:112, 225 mg/kg
Administration:Intraperitoneal or oral, daily
Result:Significantly extended survival, improved body weight and motor performance, delayed the neuropathological sequela and significantly altered the levels of Tgase activity and N(Sigma)-(gamma-L-glutamyl)-L-lysine (GGEL) levels.
分子量

225.20

性状

Solid

Formula

C4H14Cl2N2S2

CAS 号

56-17-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)