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1-Ethynylnaphthalene
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
1-Ethynylnaphthalene图片
CAS NO:15727-65-8
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
100mg电议
500mg电议

产品介绍
1-Ethynylnaphthalene是细胞色素P4501B1的选择性抑制剂。
Cas No.15727-65-8
别名1-乙炔萘;1-乙炔基萘
Canonical SMILESC#CC1=C2C=CC=CC2=CC=C1
分子式C12H8
分子量152.19
溶解度DMSO : ≥ 125 mg/mL (821.34 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1.

1-Ethynylnaphthalene, selective inhibitor of cytochrome P450 IB1, does not affect 2-hydroxylation but inhibits 4-hydroxylation by 38%. At higher concentrations, 1-Ethynylnaphthalene inhibits 2-hydroxylation of 2-Hydroxylation of estradiol (E2) by ~30% and 4-hydroxylation of E2 by up to 80%[1].

[1]. Liehr JG, et al. 4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis. Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9220-4.