CAS NO: | 1208315-24-5 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | N6022 is a potent, selective, reversible, and efficaciousS-Nitrosoglutathione reductase(GSNOR)inhibitor withIC50of 8 nM. | ||||||||||||||||
IC50& Target | IC50: 8 nM (GSNOR)[2] | ||||||||||||||||
体外研究 (In Vitro) | N6022 shows concentration-dependent binding to rat plasma proteins. N6022 has more effect on ATP at lower drug concentrations (20 μM) than on GSH[1]. N6022 binds in the GSNO substrate binding pocket like a competitive inhibitor with an IC50of 8 nM and a Kiof 2.5 nM. N6022 is uncompetitive with cofactors NAD+and NADH[2]. | ||||||||||||||||
体内研究 (In Vivo) | N6022 (50 mg/kg)-treated rats show a slight increase in the incidence of granulomas. In serum, N6022 remains in solution up to 5 mg/mL[1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 414.46 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C24H22N4O3 | ||||||||||||||||
CAS 号 | 1208315-24-5 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 46 mg/mL(110.99 mM) H2O :< 0.1 mg/mL(insoluble) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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