CAS NO: | 26791-73-1 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Xanthatin is isolated from Xanthium strumarium leaves. Xanthatin exhibits strong antitumor activities against a variety ofcancercells throughapoptosis persuasion and shows anti-inflammatory activities by inhibiting PGE2 synthesisand 5-lipoxygenase activity[1]. Xanthatin is a potent and orally active inhibitor ofVEGFR2 kinaseactivity with anIC50of 3.8 μM and prominently blocks the phosphorylation of VEGFR2 at Tyr951 site. Xanthatin inhibits angiogenesis and has the potential for the investigation of breastcancer[2]. | ||||||||||||||||||||||||
IC50& Target | IC50: apoptosis; 3.8 μM (VEGFR2 kinase); 2.63 μg/mL (T. b. brucei)[1] | ||||||||||||||||||||||||
体外研究 (In Vitro) | Xanthatin is against T. b. brucei with an IC50 value of 2.63 μg/mL and exhibits weak irreversible inhibition of parasite specific trypanothione reductase[1].Xanthatin (0-40 μM; 24 hours) has obscure inhibition effect on the proliferation of HUVEC in the absence of VEGF[2].Xanthatin (5-40 μM; 24 hours) inhibits breast cancer cell proliferation in a dose responsive manner. Xanthatin inhibits HCC1937, MDA-MB-415, SK-BR-3, MCF-7 and MDA-MB-231 with IC50values of 81 μM, 31 μM, 38 μM, 30 μM, and 17 μM, respectively[2].Xanthatin (0-10 μM; 24 hours) dose dependently suppresses the phosphorylation of STAT3 (Ser727), at the same time, it also results in a rapid dephosphorylation of down-stream kinases of STAT3, including PI3K and Akt, including PI3K (p-PI3K p85tyr458) and Akt[2]. Cell Proliferation Assay[2]
Cell Viability Assay[2]
Western Blot Analysis[2]
| ||||||||||||||||||||||||
体内研究 (In Vivo) | Xanthatin (intragastric administration; 20 mg/kg; once daily; 25 days) leads to significant inhibition of tumor volume. And this compound is well-tolerated and exhibits no significant difference in weight compares to the vehicle group[2].
| ||||||||||||||||||||||||
分子量 | 246.30 | ||||||||||||||||||||||||
性状 | Solid | ||||||||||||||||||||||||
Formula | C15H18O3 | ||||||||||||||||||||||||
CAS 号 | 26791-73-1 | ||||||||||||||||||||||||
中文名称 | 苍耳亭 | ||||||||||||||||||||||||
结构分类 |
| ||||||||||||||||||||||||
来源 |
| ||||||||||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||||||||||
储存方式 | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) | ||||||||||||||||||||||||
溶解性数据 | In Vitro: DMSO : 100 mg/mL(406.01 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
|