CAS NO: | 1029317-21-2 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | PF-4191834 (PF-04191834) is an orally active, noniron chelating, and non-redox inhibitor of the5-Lipoxygenase (5-LOX)(IC50=229 nM), displays ~300-fold selectivity for5-LOXover12-LOXand15-LOX, shows no activity toward the cyclooxygenase enzymes, and is effective in inflammation and pain[1]. | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | PF-4191834 (PF-04191834) inhibits the synthesis of the 5-LOX products 5-HETE, 5-oxo-ETE, LTB4, and LTE4 with estimated IC50values between 100 and 190 nM and do not inhibit significantly the COX-1/2 enzymes or the 12- or 15-LOX enzymes at concentrations up to 30 μM[1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 393.50 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C22H23N3O2S | ||||||||||||||||
CAS 号 | 1029317-21-2 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(254.13 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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