CAS NO: | 30271-38-6 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
2mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
生物活性 | 24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator ofN-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factorsLXR. | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | 24S-hydroxycholesterol oxysterol-generating enzyme Cyp46a1 is overexpressed during the angiogenic switch in rat insulin promoter 1-T-antigen 2 (RIP1-Tag2) pNET formation[1]. | ||||||||||||||||
体内研究 (In Vivo) | Hypoxia inducible factor-1a (HIF-1α) controls the overexpression of the enzyme Cyp46a1, which generates the oxysterol 24-hydroxycholesterol in a pancreatic neuroendocrine tumor (pNET) model commonly used to study neoangiogenesis. The activation of the HIF-1α-24S-HC axis ultimately leads to the induction of the angiogenic switch through the positioning of proangiogenic neutrophils in proximity to Cyp46a1+islets[1]. 24-hydroxycholesterol levels are increased at 2-4 months in the untreated 5XFAD mouse brain and then became similar to those in the B6SJL mouse brain[2]. | ||||||||||||||||
分子量 | 402.65 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C27H46O2 | ||||||||||||||||
CAS 号 | 30271-38-6 | ||||||||||||||||
中文名称 | 24-羟基胆固醇 | ||||||||||||||||
结构分类 |
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来源 | brain | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 25 mg/mL(62.09 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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