CAS NO: | 918348-67-1 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | BMS-779788 is aLXRpartial agonist withIC50values of 68 nM forLXRαand 14 nM forLXRβ. | ||||||||||||||||
IC50& Target | IC50: 68 nM (LXRα); 14 nM (LXRβ)[1] | ||||||||||||||||
体外研究 (In Vitro) | The LXR selective partial agonist BMS-779788 is identified with potent induction of ATP binding transporters ABCA1 and ABCG1 in human whole blood (EC50=1.2 μM, 55% efficacy)[2]. | ||||||||||||||||
体内研究 (In Vivo) | BMS-779788 induces LXR target genes in bloodin vivowith an EC50=610 nM, a value similar to itsin vitroblood gene induction potency. BMS-779788 is 29- and 12-fold less potent than the full agonist T0901317 in elevating plasma triglyceride and LDL cholesterol, respectively, with similar results for plasma cholesteryl ester transfer protein and apolipoprotein B[1]. In mice BMS-779788 displays peripheral induction of ABCA1 at 3 and 10 mpk doses with no significant elevation of plasma or hepatic triglycerides at these doses, showing an improved profile compared to a full pan-agonist[2]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 509.06 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C28H29ClN2O3S | ||||||||||||||||
CAS 号 | 918348-67-1 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(196.44 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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