CAS NO: | 1672691-50-7 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | JZP-MA-11 is a positron emission tomography (PET) ligand targeting theendocannabinoid α/β-hydrolase domain 6 (ABHD6)enzyme. JZP-MA-11 selectively inhibits ABHD6 with anIC50value of 126 nM. JZP-MA-11 can cross the blood-brain barrier (BBB). [18F]JZP-MA-11 has the potential for preclinical evaluation targeting the brain ABHD6 in mice and nonhuman primate (NHP)[1]. | ||||||||
体外研究 (In Vitro) | JZP-MA-11 (10 μM) 对表达 CB1或 CB2的 HEK293 细胞中毛喉素 (HY-15371) 刺激的 cAMP 没有影响[1]。 | ||||||||
体内研究 (In Vivo) | JZP-MA-11 (1.5 mg/kg; 静脉给药; 示踪剂注射前 20 分钟) 导致大脑、肝脏、心脏和肾脏等富含 ABHD6 的器官的放射性摄取减少[1]。
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分子量 | 336.38 | ||||||||
Formula | C15H17FN4O2S | ||||||||
CAS 号 | 1672691-50-7 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |