Nampt-IN-10 trihydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Nampt-IN-10 trihydrochloride (compound 4) 是磷酸核糖转移酶 (NAMPT) 的抑制剂。Nampt-IN-10 trihydrochloride 对 A2780 和 CORL23 细胞具有活性值，IC₅₀值分别为 5 和 19 nM。Nampt-IN-10 trihydrochloride 可以作为抗体偶联药物 (ADC) 的非限制性有效载荷。

生物活性

Nampt-IN-10 trihydrochloride (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-10 trihydrochloride shows cellular potency to A2780 and CORL23 cell lines withIC₅₀values of 5 and 19 nM, respectively. Nampt-IN-10 trihydrochloride can be used as a novel non-antimitotic payload for antibody-drug conjugate (ADC)^[1].

IC₅₀& Target

IC50: 5 nM (A2780), 19 nM (CORL23), 2 nM (NCI-H526 with c-Kit expressing), 0.4 nM (MDA-MB453 with HER2 expressing), 1 nM (NCI-N87 with HER2 expressing)^[1]

体外研究
(In Vitro)

Nampt-IN-10 trihydrochloride (0-1 μM; 72 h) 对 A2780, CORL23, c-Kit 和 HER2 的表达细胞株具有细胞毒性。

Cell Cytotoxicity Assay^[1]

Cell Line:	A2780, CORL23, NCI-H526 with c-Kit expressing, MDA-MB453 and NCI-N87 with HER2 expressing cell lines
Concentration:	0-1 μM
Incubation Time:	72 hours
Result:	Showed cytotoxicity to A2780, CORL23, NCI-H526 with c-Kit expressing, MDA-MB453 and NCI-N87 with HER2 expressing cells with IC₅₀values of 5, 19, 2, 0.4 and 1 nM, respectively.

分子量

582.92

Formula

C₂₇H₃₁Cl₃FN₅O₂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.