CAS NO: | 590368-25-5 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | Upamostat (WX-671) is aserine proteaseinhibitor. Upamostat is the orally available prodrug of the WX-UK1, which is a urokinase plasminogen activator (uPA) inhibitor. | ||||||||||||||||
IC50& Target | Serine protease, uPA[1] | ||||||||||||||||
体外研究 (In Vitro) | Upamostat is the urokinase plasminogen activator (uPA) inhibitor. Upamostat is the oral pro-drug of the active metabolite WX-UK1, a novel uPA inhibitor[1]. Upamostat inhibits the urokinase-type plasminogen activator (uPA) system, which plays a major role in tumor invasion and metastasis. Upamostat is the orally available amidoxime- (i.e. hydroxyamidine-) prodrug of the pharmacologically active form, WX-UK1[2]. | ||||||||||||||||
体内研究 (In Vivo) | The validated method is used to evaluate the pharmacokinetics of Upamostat (Mesupron) in rats. The mean plasma concentrations of Upamostat after a single intravenous injection of 2 mg/kg in five rats are measured. The substance decays in a mono-phasic pattern with a terminal half-life of 0.5 h; its volume of distribution is 2.0 L/kg, and clearance is about 2.7 L/h/kg[3]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 629.81 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C32H47N5O6S | ||||||||||||||||
CAS 号 | 590368-25-5 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 250 mg/mL(396.95 mM) *"≥" means soluble, but saturation unknown. 配制储备液
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