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TM-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TM-1图片
CAS NO:921099-13-0
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
TM-1 是丙酮酸脱氢酶激酶 (PDHK) 的强效抑制剂。TM-1 抑制PDHK1PDHK2的活性,IC50分别为2.97 μM 和 5.2 μM。TM-1 能够阻断丙酮酸脱氢酶复合物 (PDHC) 磷酸化,并抑制癌细胞增殖。
生物活性

TM-1 is a potent inhibitor ofpyruvate dehydrogenase kinase(PDHK1). TM-1 inhibitsPDHK1andPDHK2withIC50s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation[1].

IC50& Target

IC50: 2.97 μM (PDK1), 5.2 μM (PDK2)[1]

体外研究
(In Vitro)

TM-1 (0-10 μM) inhibits PDHK1 activity with the inhibition rate of 80.5% (dosage at 10 μM) and an IC50value of 2.97 μM[1].
TM-1 (0-2.1 μM; 12 h) shows anti-osteosarcoma activity and inhibits MG-63 cells with an EC50value of 14.5 μM[1].
TM-1 (3, 6, 12 μM; 24 h) decreases PDHC phosphorylation of both Ser293 and Ser232 sites in a dose-dependent manner[1].

Cell Viability Assay[1]

Cell Line:MG-63 cells
Concentration:3, 6, 12 μM
Incubation Time:24 hours
Result:Dramatically reduced the PDHK phosphorylation of both Ser293 and Ser232 sites at 6 or 12 μM.
分子量

468.54

性状

Solid

Formula

C26H32N2O6

CAS 号

921099-13-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month