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Okadaic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Okadaic acid图片
CAS NO:78111-17-8
包装:25 μg (124.2 μM * 250 μL in Ethanol)
市场价:2300元

产品名称
冈田酸
产品介绍
Okadaic acid 是一种海洋毒素,是蛋白质磷酸酶 (PP) 的抑制剂,包括PP1(IC50=15-50 nM)、PP2A(IC50=0.1-0.3 nM)、PP3(IC50=3.7-4 nM)、PP4(IC50=0.1 nM) 和PP5(IC50=3.5 nM),其中对 PP2A 的亲和力最显著,但不抑制 PP2C。Okadaic acid 通过抑制 PP 增加了多种蛋白的磷酸化,并具有肿瘤启动子的作用。Okadaic acid 诱导 tau 蛋白磷酸化。
生物活性

Okadaic acid, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid has a significantly higher affinity forPP2A(IC50=0.1-0.3 nM), and inhibitsPP1(IC50=15-50 nM),PP3(IC50=3.7-4 nM),PP4(IC50=0.1 nM),PP5(IC50=3.5 nM), but does not inhibit PP2C. Okadaic acid increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid induces tau phosphorylation[1][2].

IC50& Target[1]

PP1

15-50 nM (IC50)

PP2A

0.1-0.3 nM (IC50)

PP3

3.7-4 nM (IC50)

PP4

0.1 nM (IC50)

PP5

3.5 nM (IC50)

PP2B

~4000 nM (IC50)

PP7

>1000 nM (IC50)

体外研究
(In Vitro)

Okadaic acid (0-100 nM; 24 h or 48 h) inhibits the proliferation of AGS, MNK-45, Caco 2 cells[3].
Okadaic acid (10 nM; 8 hours) increases Drp1 phosphorylation and mitochondrial fission in rat cortical neurons[4].

Cell Proliferation Assay[3]

Cell Line:AGS, MNK-45 and Caco 2 cell lines
Concentration:0-100 nM
Incubation Time:24 h or 48 h
Result:Inhibited the proliferation of AGS, MNK-45, Caco 2 cells.
体内研究
(In Vivo)

Okadaic acid (100 μM; injected unilaterally to the lateral amygdala) induces Tau phosphorylation and protein aggregation in anatomically distinct brain regions 24 h post-injection[5].

分子量

805.00

性状

Liquid

Formula

C44H68O13

CAS 号

78111-17-8

中文名称

冈田酸

结构分类
  • Ketones, Aldehydes, Acids
来源

marine mollusks?

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Solution, -20°C, 2 years