CAS NO: | 78111-17-8 |
包装: | 25 μg (124.2 μM * 250 μL in Ethanol) |
市场价: | 2300元 |
生物活性 | Okadaic acid, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid has a significantly higher affinity forPP2A(IC50=0.1-0.3 nM), and inhibitsPP1(IC50=15-50 nM),PP3(IC50=3.7-4 nM),PP4(IC50=0.1 nM),PP5(IC50=3.5 nM), but does not inhibit PP2C. Okadaic acid increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid induces tau phosphorylation[1][2]. | ||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | Okadaic acid (0-100 nM; 24 h or 48 h) inhibits the proliferation of AGS, MNK-45, Caco 2 cells[3]. Cell Proliferation Assay[3]
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体内研究 (In Vivo) | Okadaic acid (100 μM; injected unilaterally to the lateral amygdala) induces Tau phosphorylation and protein aggregation in anatomically distinct brain regions 24 h post-injection[5]. | ||||||||
分子量 | 805.00 | ||||||||
性状 | Liquid | ||||||||
Formula | C44H68O13 | ||||||||
CAS 号 | 78111-17-8 | ||||||||
中文名称 | 冈田酸 | ||||||||
结构分类 |
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来源 | marine mollusks? | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Solution, -20°C, 2 years |