CAS NO: | 13721-39-6 |
包装 | 价格(元) |
10 mM * 1 mL in Water | 电议 |
500mg | 电议 |
5 g | 电议 |
10 g | 电议 |
50 g | 电议 |
生物活性 | Sodium orthovanadate is an inhibitor ofprotein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue. | ||||||||||||||||
IC50& Target | PPTPase[1]. | ||||||||||||||||
体外研究 (In Vitro) | In the presence of oxidizing agents vanadium ions exist as the hydrated monomer of Sodium orthovanadate (vanadate: HVO42-or H2VO4-) at micromolar concentations near neutral pH. Sodium orthovanadate (vanadate) also begins to polymerize at concentrations greater than 0.1 mM at neutral pH. The yellow-orange solutions of decavanadate can be converted to the colorless solutions of monomeric Sodium orthovanadate (vanadate) by dilution after a period of many hours. The process is hastened by boiling at pH 10, which encourages the kinetically sluggish depolymerization process[1]. Sodium orthovanadate could alter the phosphorylation status of ASK1 at serine 83 and threonine 845 induced by ischemia. Sodium orthovanadate could increase the tyrosine posphorylation of PTEN and further inhibit the activation of ASK1 via activating Akt during cerebral ischemia[2]. | ||||||||||||||||
分子量 | 183.91 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | Na3O4V | ||||||||||||||||
CAS 号 | 13721-39-6 | ||||||||||||||||
中文名称 | 正钒酸钠;原钒酸钠;钒酸钠 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : 8.33 mg/mL(45.29 mM;Need ultrasonic) DMSO :< 1 mg/mL (ultrasonic;warming;heat to 80℃)(insoluble or slightly soluble) 配制储备液
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