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SPH3127
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SPH3127图片
CAS NO:1399849-02-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
SPH3127 (DRI 18) 是一种新型的、高度有效的、且具有口服活性的direct renin抑制剂 (recombinant human-reninIC50=0.4 nM,human plasma renin activityIC50=0.45 nM)。SPH3127 具有抗高血压作用,可用于高血压的研究。
生物活性

SPH3127 (DRI 18) is a novel, highly potent, and orally activedirectrenininhibitor (recombinant human-reninIC50=0.4 nM, human plasmareninactivityIC50=0.45 nM). SPH3127 shows antihypertensive effect and can be used in essential hypertension research[1].

体内研究
(In Vivo)

SPH3127 (oral administration; 0-10 mg/kg; once) shows favorable bioavailability in cynomolgus monkeys[1].
SPH3127 (oral administration; 0-3 mg/kg; once) shows a hypotensive effect on tsukuba hypertensive mice[1].

Animal Model:Cynomolgus monkeys pretreated with a low-sodium diet and furosemide[1]
Dosage:0, 1, 3, and 10 mg/kg
Administration:Oral administration; 1, 3, and 10 mg/kg; once
Result:Inhibited plasma renin activity with the IC50value of 0.46 nM, and showed hypotensive effect.
Animal Model:Tsukuba hypertensive mice (THM)[1]
Dosage:0, 0.3, 1, or 3 mg/kg
Administration:Oral administration; 0, 0.3, 1, or 3 mg/kg; once
Result:Exhibited a hypotensive effect on tsukuba hypertensive mice in a dose-dependent manner from 0.3 to 3 mg/kg, and showed a maximum hypotensive effect of approximately 30 mmHg at 2-3 h after administration at any dose.
Clinical Trial
分子量

444.53

Formula

C22H32N6O4

CAS 号

1399849-02-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.