您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Remikiren
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Remikiren
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Remikiren图片
CAS NO:126222-34-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
Ro 42-5892
Ro 42-5892/001
产品介绍
Remikiren (Ro 42-5892) 是一种口服有效的、高特异性的肾素抑制剂。Remikiren 能特异性地抑制人肾素和人血浆肾素,其IC50值分别为 0.7 和 0.8 nM。Remikiren 还能降低钠耗竭的狨猴和松鼠猴的平均动脉血压。Remikiren 可用于高血压的研究。
生物活性

Remikiren (Ro 42-5892) is an orally active and highly specificrenininhibitor. Remikiren specifically inhibits humanreninand human plasmareninwithIC50values of 0.7 and 0.8 nM, respectively. Remikiren also reduces mean arterial blood pressure in sodium-depleted marmosets and squirrel monkeys. Remikiren can be used in study of hypertension[1].

IC50& Target

IC50:0.7 nM (human pure renin), 0.8 nM (plasma renin of human)[1].

体外研究
(In Vitro)

Remikiren (0-10 nM; 1-3 h) displays a considerable specificity to inhibit renin[1].

Cell Viability Assay[1]

Cell Line:Human pure renin, plasma renin of human, marmoset, squirrel monkey
Concentration:0-10 nM
Incubation Time:1-3 h
Result:Inhibited human pure renin and plasma renin of human, marmoset, squirrel monkey with IC50values of 0.7, 0.8, 1.0 and 1.7 nM, respectively.
体内研究
(In Vivo)

Remikiren (0.1, 0.3, 1, 3, 10 mg/kg; p.o.; single) reduces mean arterial blood pressure in a dose-dependent manner in sodium-depleted marmosets and squirrel monkeys[1].
Remikiren (3 mg/kg; p.o.; single) shows the duration of blood pressure decrease more than 24 h in sodium-depleted marmosets[1].

Animal Model:Marmosets and squirrel monkeys (sodium-depleted)[1].
Dosage:0.1, 0.3, 1, 3, 10 mg/kg
Administration:Oral administration; single.
Result:Decreased mean arterial pressure (MAP) by 20-25 mm Hg when at 0.1 mg/kg.
Reached the maximal decrease (30 mm Hg) of MAP with 1 mg/kg in marmosets.
Decreasesd 35 mm Hg blood pressure with 3-10 mg/kg in squirrel monkeys.
Animal Model:Marmosets (sodium-depleted)[1].
Dosage:3 mg/kg
Administration:Oral administration; single.
Result:Showed MAP fell by 30 mm Hg, which lasting more than 24 h.
分子量

630.84

Formula

C33H50N4O6S

CAS 号

126222-34-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.