Renininhibitor-1 (compound 26) is a potent and orally activerenininhibitor withIC₅₀s of 0.9, 1.8 nM for rh-renin and hPRA, respectively.Renininhibitor-1 shows antihypertensive efficacy.Renininhibitor-1 has the potential for the research of hypertension and cardiovascular/renal diseases^[1].

IC₅₀: 0.9 nM (rh-renin); 1.8 nM (hPRA)^[1]

Renin inhibitor-1 (compound 26) (10 mg/kg; p.o.) demonstrates a significantly potent hypotensive effect in tsukuba hypertensive mice^[1].

414.50

C₂₂H₃₀N₄O₄

1093082-54-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.