CAS NO: | 113082-98-7 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Enalkiren (A-64662) is a potentdipeptiderenininhibitor with anIC50of 0.78 nM in a purified renal renin-angiotensinogen system (pH=6.0). Enalkiren suppressesreninactivity, and also reduces systolic and diastolic blood pressure. Enalkiren can be used to research essential hypertension[1][2]. | ||||||||
IC50& Target | IC50: 23 nM (hamster dipeptide renin), 14 nM (human dipeptide renin), 2.3 nM (cynomolgus monkey dipeptide renin)[2] | ||||||||
体外研究 (In Vitro) | Enalkiren inhibits the endogenous renin-angiotensinogen reaction with an IC50value of 23 nM, 14 nM and 2.3 nM in hamster, human and cynomolgus monkey plasma, respectively, at pH 7.4[2]. | ||||||||
体内研究 (In Vivo) | Enalkiren (0.01-10 mg/kg; i.v.; single dosage) reduces mean arterial blood pressure in cynomolgus monkey[2].
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分子量 | 656.86 | ||||||||
Formula | C35H56N6O6 | ||||||||
CAS 号 | 113082-98-7 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |