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SR10067
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SR10067图片
CAS NO:1380548-02-6
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议

产品介绍
SR10067 是一种强效、选择性和脑渗透性 REV-ERB 激动剂。SR10067 对 Rev-Erbβ 和 Rev-Erbα 具有高亲和力,IC50值分别为 160 nM 和 170 nM。 SR10067 可用于代谢疾病和神经精神疾病的研究。
生物活性

SR10067 is a potent, selective and brain penetrantREV-ERBagonist. SR10067 has high affinity for Rev-Erbβ and Rev-Erbα withIC50values of 160 nM and 170 nM, respectively. SR10067 can be used for the research of metabolic diseases and neuropsychiatric disorders[1][2].

IC50& Target

IC50: 160 nM (Rev-Erbβ); 170 nM (Rev-Erbα)[1]

体外研究
(In Vitro)

SR10067 has high affinity for Rev-Erbβ and Rev-Erbαwith IC50values are 160 and 170 nM, respectively[1].

体内研究
(In Vivo)

SR10067 (i.p.; 30 mg/kg) has good pharmacokinetic properties in mouse[1].

Animal Model:Mice[1]
Dosage:30 mg/kg
Administration:i.p.
Result:Remained above the IC50of the receptor in plasma and brain concentrations.
Suppressed the circadian rhythm of Npas2 gene expression in the mouse hypothalamus in a single injection and had a dose-dependent effect on reduction in nocturnal wheel running activity.
Induced wakefulness and reduced SWS and REM sleep and displayed high anxiolytic activity.
分子量

465.58

性状

Solid

Formula

C31H31NO3

CAS 号

1380548-02-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL(214.79 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.1479 mL10.7393 mL21.4786 mL
5 mM0.4296 mL2.1479 mL4.2957 mL
10 mM0.2148 mL1.0739 mL2.1479 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。