STL1267

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STL1267

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1429024-58-7

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

STL1267 是一种有效的可穿过血脑屏障的REV-ERB激动剂，对 REV-ERBα 的K_i值为 0.16 μM。STL1267 没有表现出细胞毒性。STL1267 抑制 BMAL1 的基因表达。

生物活性

STL1267 is a potent and cross-the-blood-brain barrierREV-ERBagonist with aK_ivalue of 0.16 μM for REV-ERBα. STL1267 shows no cytotoxicity. STL1267 inhibits the gene expression of BMAL1^[1].

IC₅₀& Target

K_i: 0.16 μM (REV-ERBα)^[1]

体外研究
(In Vitro)

STL1267 (5 μM; 24 h) 在 HepG2 细胞中降低 BMAL1 的表达并增加 Mtnd1、Mtco1、Vicad、Lcad、Scad、Lkb1、Sirt1、Nampt、Ppargc1a 的基因表达^[1]。

Cell Viability Assay^[1]

Cell Line:	HepG2, C2C12 cells
Concentration:	0-20 μM
Incubation Time:	24 h
Result:	Showed no adverse effects on cell viability up to the maximum dose examined 20 μM.

RT-PCR^[1]

Cell Line:	HepG2 cells
Concentration:	5 μM
Incubation Time:	24 h
Result:	Decreased the gene expression of BMAL1, increased the gene expression of Mtnd1, Mtco1, Vicad, Lcad, Scad, Lkb1, Sirt1, Nampt, Ppargc1a.

体内研究
(In Vivo)

STL1267 (50 mg/kg; i.p.; once) 在小鼠体内有效抑制 BMAL1 的表达^[1]。

Animal Model:	6-8 weeks, male C57Bl/6 J mice^[1]
Dosage:	50 mg/kg
Administration:	I.p.; once
Result:	Showed a plasma half-life of 1.6 h, effectively suppressed BMAL1 expression in the liver at 12 h post-administration.

分子量

322.75

Formula

C₁₇H₁₁ClN₄O

CAS 号

1429024-58-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.