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Vanoxerine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Vanoxerine图片
CAS NO:67469-69-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
GBR 12909
I893
产品介绍
Vanoxerine (GBR-12909) 是竞争性的,有效选择性的多巴胺再摄取(dopamine reuptake)抑制剂。Vanoxerine (GBR-12909) 与多巴胺转运体 (DAT) 上的靶点结合。
生物活性

Vanoxerine (GBR-12909) is a competitive, potent, and highly selectivedopamine reuptakeinhibitor (Ki=1 nM). Vanoxerine (GBR-12909) binds to the target site on thedopamine transporter(DAT)[1].

IC50& Target

Ki: 1 nM (dopamine reuptake)[1]

体外研究
(In Vitro)

Vanoxerine (GBR-12909) inhibits the uptake of dopamlne (DA), with an IC50in the low nanomolar range, and is several-fold less potent as inhibitors of the uptake of noradrenaline and 5-HT[2].
Vanoxerine (GBR-12909) is also an oral, mixed ion channel blocker with IKr, INa, and L-type calcium channel activity[3].

体内研究
(In Vivo)

Vanoxerine (GBR-12909) (2.5-20 mg/kg; i.p.) significantly increases the ambulatory activity[3].

Animal Model:Male mice(ddY strain at 6 weeks of age)[3]
Dosage:2.5, 5, 10, 20 mg/kg
Administration:Intraperitoneal injection
Result:The ambulatory activity of mice increased in a dose-dependent manner, with a maximal increase at 30 min after the administration.
Clinical Trial
分子量

450.56

Formula

C28H32F2N2O

CAS 号

67469-69-6

中文名称

伐诺司林;伐洛司林

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.