Zimelidine 是一种有效的选择性的serotonin 5-HT摄取和SERT抑制剂。Zimelidine 是一种抗抑郁药。
| 生物活性 | Zimelidine is a potent and selective inhibitor ofserotonin 5-HTuptake andSERT. Zimelidine is an antidepressant[1][2][3][4]. |
体内研究
(In Vivo) | Zimelidine (15 mg/kg, IP, once) reduces the development of tolerance to morphine-induced antinociception in rats[3].
Zimelidine (5 mg/kg, IP, daily for 14 days) dose not modify the responsiveness of CA3hippocampal pyramidal neurons to microiontophoreticahy applied 5-HT[2].
Zimelidine (0.2, 2 and 20 nmol/100 nL) in medial amygdaloid nucleus (MeA) evokes dose dependent hypophagic effects in fasted rats[4].
| Animal Model: | Male Wistar albino rats (160-180 g, n=72)[3] | | Dosage: | 15 mg/kg | | Administration: | IP, once | | Result: | Significantly attenuated the development and expression of morphine tolerance. The maximal antinociceptive effect of Zimelidine was obtained at the 60 minutes measurements in the zimelidine group and at the 30 minutes measurements in the morphine tolerant group by the tail-flick and hot-plate tests. Administration of zimelidine with morphine showed additive analgesic effect. |
| Animal Model: | Sprague-Dawley rats (150 to 250 g, Ten, male)[2] | | Dosage: | 5 mg/kg | | Administration: | IP, daily for 14 days | | Result: | Did not modify the responsiveness of CA3hippocampal pyramidal neurons to microiontophoreticahy applied 5-HT. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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