IONIS-MAPTRx (BIIB080) 是第一个降低 Tau 的反义寡核苷酸 (ASO)。IONIS-MAPTRx 具有研究阿尔茨海默病的潜力。
| 生物活性 | IONIS-MAPTRx (BIIB080) is the first Tau-lowering antisense oligonucleotide (ASO). IONIS-MAPTRx has the potential for the research of Alzheimer Disease[1]. |
体内研究
(In Vivo) | Intrathecal administrations of IONIS-MAPTRx in nonhuman primates showed a mean MAPT mRNA reduction of 77% in frontal cortex and 74% in hippocampus without dose-limiting side effects[1].
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| Clinical Trial | |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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