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LYP-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LYP-IN-1图片
CAS NO:1404436-51-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
LYP-IN-1 是一种有效、选择性和特异性的LYP抑制剂,其KiIC50的值分别为 110 nM 和 0.259 μM。LYP-IN-1 对一些 PTPs 也有选择性,如 SHP1 (IC50=5 μM) 和 SHP2 (IC50=2.5 μM)。LYP-IN-1 在 T 细胞和肥大细胞中表现出高效的细胞活性。LYP-IN-1 可用于研究自身免疫性疾病。
生物活性

LYP-IN-1 is a potent, selective and specificLYPinhibitor with aKiand anIC50of 110 nM and 0.259 μM, respectively. LYP-IN-1 also has selectivity for a large panel of PTPs, such as SHP1 (IC50=5 μM) andSHP2(IC50=2.5 μM). LYP-IN-1 exhibits highly efficacious cellular activity in T- and mast cells. LYP-IN-1 can be used for the study of autoimmune disorders[1].

IC50& Target

IC50: 0.259 μM (LYP)
Ki: 110 nM (LYP)[1]

体外研究
(In Vitro)

LYP-IN-1 has inhibitory activity toward a panel of mammalian PTPs including SHP1, SHP2, PTP-Meg2, FAP1 and PTP-PEST, with IC50values of 5 μM, 2.5 μM, 0.59 μM, 0.39 μM, and 0.8 μM, respectively[1].
LYP-IN-1 (15 μM) increases both basal and TCR-stimulated phosphorylation of ZAP-70 on Tyr319 in JTAg cells[1].
LYP-IN-1 (15 μM) treatment of mouse thymocytes effectively causes an increase in the activation of double-positive (DP) thymocytes, it increased surface expression of CD69 (a marker of T cell activation) and Nur77[1].

分子量

501.91

性状

Solid

Formula

C28H20ClNO6

CAS 号

1404436-51-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month