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S-2 Methanandamide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
S-2 Methanandamide图片
CAS NO:157182-48-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Cas No.157182-48-4
别名(S)-(+)-Arachidonyl-2'-Hydroxy-1'-Propylamide
化学名N-(2S-hydroxypropyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Canonical SMILESCCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCC(C)O
分子式C23H39NO2
分子量361.6
溶解度≤10mg/ml in DMSO;10mg/ml in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

S-2 methanandamide is a CB1 receptor ligand.

The cannabinoid receptor type 1 (CB1), is a G protein-coupled cannabinoid receptor located mainly in the central and peripheral nervous system. CB1 is also expressed in several cells relating to metabolism, such as muscle cells, fat cells, liver cells, and the digestive tract. The CB1 receptor has been involved in the maintenance of homeostasis in health and disease, preventing the development of excessive neuronal activity, reducing pain and other inflammatory symptoms. Enhanced receptor expression has been identified in human hepatocellular carcinoma tumor samples and human prostate cancer cells [2].

S-2 methanandamide was the second most potent CB1 receptor agonist in the methanandamide series. S-2 methanandamide activated the CB1 receptor with a Ki value of 26 nM. S-2 methanandamide was less prone to FAAH inactivation. S-2 methanandamide inhibited the murine vas deferens twitch response with an IC50 value of 47 nM.

References:
[1] Abadji V, Lin S, Taha G, et al.  (R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability[J]. Journal of medicinal chemistry, 1994, 37(12): 1889-1893.
[2] Howlett A C.  Cannabinoid receptor signaling[M]//Cannabinoids. Springer Berlin Heidelberg, 2005: 53-79.