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Anisodamine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Anisodamine图片
CAS NO:55869-99-3
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Anisodamine (6-Hydroxyhyoscyamine) 是一种颠茄生物碱,是一种非亚型选择性毒蕈碱,也是一种烟碱型胆碱受体拮抗剂。
Cas No.55869-99-3
别名山莨菪碱; 6-Hydroxyhyoscyamine
化学名αS-(hydroxymethyl)-benzeneacetic acid, (1R,3S,5R,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
Canonical SMILESO=C([C@H](CO)C1=CC=CC=C1)O[C@@H]2C[C@@H](N3C)[C@@H](O)C[C@@H]3C2
分子式C17H23NO4
分子量305.4
溶解度25mg/mL in ethanol or DMF, 20mg/mL in DMSO, 13.65mg/mL in Water
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Anisodamine is a natural tropane alkaloid shown to be a weak antagonist of α1-adrenoceptors, blocking WB-4101 and clonidine binding in brain membrane preparations with pKi values of 2.63 and 1.61, respectively.[1] Anisodamine also has antioxidant effects that may protect against free radical-induced cellular damage.[2] Anisodamine is predominantly found in the roots of A. tanguticus, which is used in traditional Chinese medicine for topical applications.[3]

Reference:
[1]. Varma, D.R., and Yue, T.L. Adrenoceptor blocking properties of atropine-like agents anisodamine and anisodine on brain and cardiovascular tissues of rats. British Journal of Pharmacology 87(3), 587-594 (1986).
[2]. Poupko, J.M., Baskin, S.I., and Moore, E. The pharmacological properties of anisodamine. Journal of Applied Toxicology 27(2), 116-121 (2007).
[3]. Ma, L., Gu, R., Tang, L., et al. Important poisonous plants in tβ ethnomedicine. Toxins (Basel) 7(1), 138-155 (2015).