| CAS NO: | 16326-32-2 |
| 包装 | 价格(元) |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 1g | 电议 |
| Cas No. | 16326-32-2 |
| 别名 | r-亚麻酸甲酯,Methyl GLA,Methyl γ-Linolenate |
| 化学名 | 6Z,9Z,12Z-octadecatrienoic acid, methyl ester |
| Canonical SMILES | CCCCC/C=C\C/C=C\C/C=C\CCCCC(OC)=O |
| 分子式 | C19H32O2 |
| 分子量 | 292.5 |
| 溶解度 | ≤100mg/ml in DMSO;100mg/ml in dimethyl formamide |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | γ-Linolenic Acid methyl ester is a weak leukotriene B4 (LTB4) receptor antagonist. LTB 4, a potent neutrophil chemoattractant, is present at high concentrations in psoriatic lesions, bronchoalveolar lavage in asthmatics and rectal dialysates in patients with inflammatory bowel disease. In vitro: γ-Linolenic acid methyl ester is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets and dietary supplements. GLA was identified as an ω-6 fatty acid which could be elongated to arachidonic acid for endogenous eicosanoid synthesis. GLA was found to be a weak leukotriene B4 (LTB4) receptor antagonist, which was able to inhibit [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 μM [1]. In vivo: In an in-vivo model of LTB4-induced bronchoconstriction, ricinelaidic acid andγ-Linolenic acid methyl ester at a 1 mg/kg i.v. dose could result in 46% and 53% inhibition, respectively, indicating that essential fatty acids are LTB4 receptor antagonists, which may account in part for their reported anti-inflammatory activities [1]. Clinical trial: So far, no clinical study has been conducted. Reference: |
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