| CAS NO: | 137566-83-7 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 137566-83-7 |
| 化学名 | 1-O-hexadecyl-2-O-acetyl-sn-glyceryl-3-phosphoryl(N,N,N-trimethyl)hexanolamine |
| Canonical SMILES | CCCCCCCCCCCCCCCCOC[C@@H](OC(C)=O)COP(OCCCCCC[N+](C)(C)C)([O-])=O |
| 分子式 | C30H62NO7P |
| 分子量 | 579.8 |
| 溶解度 | ≤23mg/ml in ethanol;0.5mg/ml in DMSO;1.5mg/ml in dimethyl formamide |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Hexanolamino PAF C-16 is a PAF analog with PAF agonist/antagonist properties. Platelet activating factor (PAF; C16), a phospholipid mediator of inflammation, is secreted by several cell types including arterial endothelial cells, and can activate polymorphonuclear leucocytes and monocytes via specific cell surface receptors. PAF also stimulates the production of active oxygen species by human monocyte - derived macrophages [1]. Hexanolamino PAF C-16, a PAF analog with an increased inter-ionic distance in the polar head group, showed a greater potency in macrophages than platelets. In human monocyte-derived macrophages, Hexanolamino PAF C-16 was an antagonist and specifically inhibited the generation of superoxide ion (02-) and hydrogen peroxide (H202) in response to PAF [1]. In both rabbit platelets and guinea-pig macrophages, Hexanolamino PAF C-16 acted as a partial agonist [2]. References: |
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