CAS NO: | 914613-35-7 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
Cas No. | 914613-35-7 |
别名 | 坎地沙坦EP杂质E |
化学名 | 2-ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester |
Canonical SMILES | O=C(OC(C)OC(C1=C(N(CC2=CC=C(C3=C(C4=NN=NN4CC)C=CC=C3)C=C2)C(OCC)=N5)C5=CC=C1)=O)OC6CCCCC6 |
分子式 | C35H38N6O6 |
分子量 | 638.7 |
溶解度 | ≤30mg/ml in DMSO;30mg/ml in dimethyl formamide |
储存条件 | Store at -20℃ |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | 1H-1-ethyl Candesartan Cilexetil, which is a process-related impurity commonly found in the bulk synthesis of candesartan cilexetil, is a potent, long-acting, and selective angiotensin II type 1 receptor (AT1) antagonist. Angiotensin II is a peptide that is mainly generated by the angiotensin converting enzyme and chymase, which plays a vital role in regulating blood pressure and sodium homeostasis via specific receptors including AT1[1]. AT1, localized in the kidney, heart, brain, adrenal gland, adipocytes, vascular smooth muscle cells, platelets, and placenta, is a major component of the renin-angiotensin system. Furthermore, AT1 mediates the classical biological actions of angiotensin II. Also, AT1 has seven helical transmembrane domains, which is the characteristic of the superfamily of G-protein-coupled receptors. Carboxyl-terminal region structure of AT1 plays important roles in receptor internalization, desensitization and phosphorylation [2]. In vitro: Up to now, in vitro study of 1H-1-ethyl candesartan cilexetil is still in the development stage. In vivo: Up to now, in vivo study of 1H-1-ethyl candesartan cilexetil is still in the development stage. References: |